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1.
Article in English | IMSEAR | ID: sea-166805

ABSTRACT

Chronic wounds such as decubitus ulcer remain challenging due to their integrated and overlapping phases. The matrix metalloproteinases (MMPs) enzymes, whose main function is to degrade all kinds of extracellular matrix (ECM) proteins, aid cellular migration and extracellular remodeling. MMPs, in the wound bed, allow the lysis of the dead tissues, by which the macrophages task becomes easier to digest the dead cells. MMPs activities should be monitored and inhibited as the healing process proceeds. If MMPs are not inhibited in time, they will break down tissue to attack the ECM itself creating chronic wounds. In the current work, conjugated linoleic acid (CLA) and ricinoleic acid (RA) are extracted from commercial oils as MMPs inhibitors. A pharmaceutical carrier is formulated containing chitosan fine particles, impregnated silver nanoparticles into microcrystalline cellulose, CLA and RA. Carrier and the active ingredients were prepared and characterized by spectral and morphological analysis. The final formulation was examined for antimicrobial, cytotoxicity, and in-vivo wound healing activity. Results showed a strong inhibitory activity against the tested pathogenic microorganisms for the silver contacting samples. The rates of wound closures during wound healing in diabetic male-rats of formulas containing ricinoleic acid was faster than that containing conjugated linoleic acid.

2.
Article in English | IMSEAR | ID: sea-152079

ABSTRACT

Aim of the study was to assess the renoprotective effect of Carum carvi essential oil. Thirty male albino rats were divided into three groups: normal control (group A), diabetic positive control (group B), and experimental (group C) receiving Carum carvi oil as a renoprotective agent at 10 mg/kg of body weights orally. Group B and C rats received STZ (60 mg/kg) for induction of diabetes. Rats with fasting blood glucose levels over 200mg /dl were considered diabetic. Blood samples were collected on the 22 th day for the determination of glutathione peroxidase and glucose. Kidneys were also extracted for examination. Carum carvi oil was analysed using the GC and GC/MS analysis. The major components of caraway essential oil were Carvone (70.1%) followed by γ – Terpinene (12.6%) and Limonene (5.5%) in addition to some minor compounds including Linalool (0.7%), Thymol (0.5%), γ –Cadinene (0.5%), α- Farnesene (0.4%), δ- Cadinene (0.4%). The diabetic group rats showed an increase in the serum level of glucose, and decrease in glutathione peroxidase. 10 mg/kg body weight dose of Carum carvi oil significantly corrected these parameters.The morphological examination of group B rats kidneys showed glomerular and tubular degeneration with massive cellular infiltration, hemorrhage in interstitial tissue and deformed renal tissue architecture. Whereas the kidney rats in group C showed marked improvement with minor pathological changes. Conclusion: Carum carvi oil showed renoprotection against diabetic nephropathy. This could be contributed to Carum carvi constituents, especially carvone , γ –Terpinene and Limonene which have strong anti-oxidant activity.

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